Small molecules & peptides

Gluc-[Lys0,Lys(ivDde)5]-TOCA

Precursor for Gluc-Lys([¹⁸F]FP)-TOCA

(Nα-(1-deoxy-D-fructosyl)-[Lys0-Tyr3-Lys(Dde)5]-octreotate; Precursor for [¹⁸F]FP-Gluc-TOCA; N-α-(1-deoxy-D-fructosyl)-KfCYw-K(ivDde)-TCT-OH, cyclic C2,7; Gluc-Lys([¹⁸F]FP)-TOCA = Nα-(1-deoxy-D-fructosyl)-Nε-(2-[¹⁸F]fluoropropionyl)-; Lys0-Tyr3-octreotate

Sequence: (1-deoxy-D-fructosyl)-Lys-D-Phe-Cys-Tyr-D-Trp-Lys(ivDde)-Thr-Cys-Thr-OH, cyclic disulfide

Quality

Research Chemical

Characteristics

Molar mass 1545.82

CAS RN [not yet assigned]

Purity ≥ 95 %

  • Colorless to off-white freeze-dried solid
  • soluble in dimethyl sulfoxide, water
  • packaged in dark screw cap vials

Certificates

CoA: appearance, MS (identity), HPLC (purity)

Literature

Meisetschlaeger G. et al. Gluc-Lys([¹⁸F]FP)-TOCA PET in Patients with SSTR-Positive Tumors: Biodistribution and Diagnostic Evaluation Compared with [¹¹¹In]DTPA-Octreotide. J. Nucl. Med. 2006, 47, 566–573.

Vaidyanathan G. et al. Synthesis and Evaluation of Glycosylated Octreotate Analogues Labeled with Radioiodine and ²¹¹At via a Tin Precursor. Bioconjugate Chem. 2006, 17, 195–203.

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