Small molecules & peptides

Aloxistatin

Cell-permeable and irreversible broad-spectrum cysteine protease inhibitor

E 64d;E 64c ethyl ester;2-​Oxiranecarboxylic acid, 3-​[[[(1S)​-​3-​methyl-​1-​[[(3-​methylbutyl)​amino]​carbonyl]​butyl]​amino]​carbonyl]​-​, ethyl ester, (2S,​3S)​-

(2S,3S)-ethyl 3-((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylate

Quality

Research Chemical

Characteristics

Molar mass 342.44

CAS RN [88321-09-9]

Purity ≥ 97 %

  • White to off-white solid
  • soluble in ethanol, chloroform, methanol

Certificates

CoA: appearance, ¹H and ¹³C NMR spectra (identity), ESI-MS (identity), HPLC, residual solvents (dichloromethane, ethanol, ethyl acetate, heptane, MTBE), assay (difference calculation), Water content

Literature

Kim, J.C. et al. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology 1995, 208, 1–8.

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