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Catalogue Number |
Product | Order number / Unit |
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| 6040 | (S)-(+)-Desmethyl-Rolipram |
6040.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities. 
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Precursor for S-(+)-[11C]Rolipram
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| Molar Mass: 261.32 | ||
| C15H19NO3 | ||
| [347148-60-1] | ||
| Colourless solid packaged in dark glass screw cap vials. | ||
| Purity: > 95 % | ||
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Certificates:
CoA; 1H NMR spectrum |
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Chemical Name: CA index name: 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-hydroxyphenyl]-, (4S)- |
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Synonymes: S-Desmethyl-Rolipram; (+)-Desmethyl-Rolipram |
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Literature: 1. Kenk M. et al. In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nucl. Med. Biol. 2007, 34, 71-77. |
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| 2. Parker C.A. et al. Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. Synapse 2005, 55, 270-279. | ||
| 3.Lourenco C.M. et al. Characterization of R-[11C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl. Med. Biol. 2001, 28, 347-358. | ||
| 4. Tsukada H. et al. Facilitation of dopaminergic neural transmission does not affect [11C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type-IV actvity through D1 receptors: PET studies in the conscious monkey brain. Synapse 2001, 42, 258-265. | ||
| date of product catalogue issue: 05 April 2012 | ||
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