ABX Datasheet Product Number 4500

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ABX advanced biochemical compounds


Catalogue Number	Product	Order number / Unit

4500	Norbinaltorphimine dihydrochloride	4500.0010: 10 mg per vial Please inquire for customized filling and bulk quantities.
	Highly selective kappa opioid receptor antagonist


	Molar Mass: 734.71
	C₄₀H₄₃N₃O₆ ⋅ 2 HCl
	[113158-34-2]
	Norbinaltorphimine free base: [105618-26-6]
	Tan solid packaged in dark glass screw cap vials.


	Purity: > 95 %
	Certificates: CoA; ¹H NMR spectrum
	Chemical Name: 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, hydrochloride (1:2), (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-; 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, dihydrochloride, [8R-(4bS,8α,8aβ,10aα,11β,14aS,19aα,20bβ)]-; 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, dihydrochloride, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-
	Synonymes: 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR), dihydrochloride salt; NorBNI; N-Desmethylbinaltorphimine; N-Demethylbinaltorphimine dihydrochloride
	Literature: 1. Portoghese P.S. et al. Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sci. 1987, 40, 1287-1292.
	2. Takemori A.E. et al. Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J. Pharmacol. Exp. Ther. 1988, 246, 255-258.
	3. Lambert P.D. et al. The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat. Brain Res. 1993, 629, 146-148.


	date of product catalogue issue: 05 April 2012

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