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ABX  advanced biochemical compounds   


Catalogue
Number
Product Order number / Unit

107 Mannose Triflate PLUS, ultra pure 107.0020: 20 mg per vial
107.0025: 25 mg per vial
107.0040: 40 mg per vial
Please inquire for customized filling and bulk quantities.

 
Precursor for [18F]FDG
(2-[18F]Fluoro-2-deoxy-D-glucose)
Manufactured according to GMP requirements for APIs (ICH Q7)
Pharmaceutical grade (EDMF/DMF)
Molar Mass: 480.37
C15H19F3O12S
[92051-23-5]
Colourless or nearly colourless crystals packaged in clear glass vials (10 ml headspace) with teflon-faced rubber stoppers, tear-off crimp caps, argon flushed.
Melting range 119 - 122 degC
Soluble in acetonitrile, DMSO, methanol, acetone; insoluble in aqueous media.
Purity: > 99 %
Certificates:
CoA with 1H; 19F NMR; and IR specta; specific optical rotation and melting point (identity); HPLC; 19F NMR; HS-GC; and thermogravimetry (chemical purity); testing for bacterial endotoxines and sterility (microbiological purity)
Chemical Name:
CA index name: beta-D-mannopyranose, 1,3,4,6-tetraacetate 2-(trifluoromethane-sulfonate)
Synonymes:
TATM; mannose triflate; 1,3,4,6-tetra-O-acetyl-2-O-trifluoro-methanesulfonyl-beta-D-mannopyranose
Literature:
1. Hamacher K. et al. Efficient stereospecific synthesis of no-carrier-added 2-[18F]fluoro-2-deoxy-D-glucose using amino-polyether supported nucleophilic substitution. J. Nucl. Med. 1986, 27, 235-238.
2. Padgett H. et al. Computer-controlled radiochemical synthesis: a chemistry process control unit for the automated production of radiochemicals. Appl. Radiat. Isot. 1989, 40, 433-445.
3. Pavliak V. et al. A short synthesis of 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-beta-D-glucopyranose and the corresponding alpha-glucosyl chloride from D-mannose. Carbohydr. Res. 1991, 210, 333-337.
4. Chirakal R. Traces of fluorine containing impurities in the mannose triflate and their adverse effect on the radiochemical yield of 2-18FDG. XIIth ISRC; Uppsala, Sweden 1997, 214-216.
date of product catalogue issue: 04 July 2014

 
 
 

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