Pittsburgh Compound B (PiB) precursor - 6-OH-BTA-0
Pittsburgh Compound-B (PIB) is a carbon-11-labelled benzothiazole derivative of the dye thioflavin T and is used for imaging beta-amyloid (Aβ), one of the pathologic hallmarks of Alzheimer's disease.[1] [11C]PiB was the first widely used PET radiotracer with specificity for Aβ aggregates in humans. It has a high affinity and selectivity for Aβ plaques and other Aβ-containing lesions. Despite having been in use for more than 20 years and the approval of several 18F-fluorinated Aβ tracers, it remains the gold standard for Aβ imaging.[2] This is also due to the broad availability of the precursor and reference standards for use in research and development, as well as in defined clinical applications (e.g. approved compassionate use program, IND, IMPD, etc.).
[1] Klunk, W. E. et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004, 55, 306-319. [2] Myburgh P. J. et al. Two decades of [11C]PiB synthesis, 2003-2023: a review. Am. J. Nucl. Med. Mol. Imaging 2024, 14, 48-62.
ABX offers the research grade (ABX prod. no. 5100) as well as the GMP (ABX prod. no. 5101) precursor and the reference standards.
ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.
Based in Radeberg, Germany, and founded in 1997, our team of about 400 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.
ABX is the only service provider of radiopharmaceutical production with a complete and independent supply chain – from precursor or peptide to excipients and sterile disposables.
